Incidental detection of congenital Robertsonian translocation at diagnosis of Philadelphia chromosome-positive acute lymphocytic leukemia

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  • YAMAGUCHI Tsukasa
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • IGARASHI Aiko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • KAWAMURA Machiko
    Department of Hematology, Saitama Cancer Center
  • OZASA Yuka
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University
  • YOSHIDA Masayuki
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University
  • KAKIHANA Kazuhiko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • SAKAMAKI Hisashi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
  • OHASHI Kazuteru
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Bibliographic Information

Other Title
  • 診断時にRobertson型転座の先天性染色体異常が判明したフィラデルフィア染色体陽性急性リンパ性白血病
  • 症例報告 第1回日本血液学会関東甲信越地方会 会長推薦演題 診断時にRobertson型転座の先天性染色体異常が判明したフィラデルフィア染色体陽性急性リンパ性白血病
  • ショウレイ ホウコク ダイ1カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ カイチョウ スイセン エンダイ シンダンジ ニ Robertsonガタテンザ ノ センテンセイ センショクタイ イジョウ ガ ハンメイ シタ フィラデルフィア センショクタイ ヨウセイ キュウセイ リンパセイ ハッケツビョウ

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Abstract

A man in his early forties who had undergone 3 years of unsuccessful treatment for infertility due to oligospermia and asthenospermia developed fever and bone pain in December 20XX. He was subsequently diagnosed with acute lymphocytic leukemia. Conventional cytogenetic analysis revealed Robertsonian translocation (RT) with der(13;14)(q10;q10) in addition to the Philadelphia (Ph) chromosome. Dasatinib and prednisolone induced complete remission (CR) with disappearance of the Ph chromosome. However, RT persisted despite achieving CR. We speculate that RT is possibly congenital in our present case and might also have been responsible for the aforementioned infertility. Hematologists should be aware of the possibility that congenital chromosomal disorders might be found incidentally through diagnostic chromosome analysis for leukemia.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (5), 481-484, 2015

    The Japanese Society of Hematology

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