Acute myeloid leukemia possibly originating from the same clone of testicular germ cell tumor

DOI Web Site PubMed 14 References

Bibliographic Information

Other Title
  • 精巣胚細胞腫瘍由来の発症が示唆された急性骨髄性白血病
  • 症例報告 第168回日本血液学会例会 : 薄井紀子例会長 推薦演題 精巣胚細胞腫瘍由来の発症が示唆された急性骨髄性白血病
  • ショウレイ ホウコク ダイ168カイ ニホン ケツエキ ガッカイ レイカイ : ハクイノリコ レイカイチョウ スイセン エンダイ セイソウハイサイボウ シュヨウ ユライ ノ ハッショウ ガ シサ サレタ キュウセイ コツズイセイ ハッケツビョウ

Search this article

Abstract

This report describes a 30-year-old man with a testicular germ cell tumor, which later developed into acute myeloid leukemia (AML) with a common chromosomal abnormality. Testicular germ cell tumors had developed at the age of 26. He was successfully treated with surgery followed by chemotherapy.<br>Four years after the onset of the germ cell tumor, he developed pancytopenia with elevated serum LDH. More than 95% of the bone marrow was occupied by blastic cells. These cells were CD13+, CD34+ but CD45- and MPO-. Amplification of the short arm of chromosome 12 was recognized by fluorescence in situ hybridization using the blastic cells in the bone marrow and the previous testicular tumor specimen. Because testicular germ cell tumor recurrence and other malignant tumors could be ruled out pathologically, he was diagnosed as having AML.<br>Allogeneic stem cell transplantation from a HLA-matched sibling donor was performed after chemotherapy. As of 19 months after the transplantation, recurrence of neither AML nor testicular tumors has been observed. Because the same genetic abnormality was observed in the testicular germ cell tumor and AML in this case, the possibility of AML having a common origin with the testicular germ cell tumor is indicated.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 54 (8), 764-768, 2013

    The Japanese Society of Hematology

References(14)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top