Detection of the primary tumor site in tumor-induced osteomalacia by indium-111 octreotide scintigraphy: A case report

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  • Takahashi Makoto
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
  • Toru Syuta
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
  • Ota Kiyohumi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
  • Izumiyama Hajime
    Department of Clinical and Molecular Endocrinology, Graduate School, Tokyo Medical and Dental University
  • Yokota Takanori
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
  • Mizusawa Hidehiro
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • Ｏｃｔｒｅｏｔｉｄｅシンチグラフィにより原因腫瘍を発見しえた腫瘍性骨軟化症性ミオパチーの１例
  • 症例報告 Octreotideシンチグラフィにより原因腫瘍を発見しえた腫瘍性骨軟化症性ミオパチーの1例
  • ショウレイ ホウコク Octreotide シンチグラフィ ニ ヨリ ゲンイン シュヨウ オ ハッケンシエタ シュヨウセイ コツ ナンカショウセイ ミオパチー ノ 1レイ

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Description

We report a 31-year-old woman with tumor-induced osteomalacia suffering from slowly progressive bilateral muscle weakness predominantly in the proximal muscles and multiple bone pains for the past 2 years. She was unable to walk or raise her arms above the shoulder. We suspected tumor-induced osteomalacia due to decreased serum phosphate and 1α, 25 (OH)2-vitamin D3 levels, low percentage of tubular reabsorption of phosphate (%TRP), adult onset, and no family history of osteomalacia. Regular imaging examinations could not detect the location of the primary tumor; however, indium-111 octreotide scintigraphy detected the causative primary mesenchymal tumor in the right sole. Pain and muscle weakness improved promptly after tumor resection, and she was able to walk 6 d postoperatively. This is the first case report in Japan describing the detection of the primary tumor site by indium-111 octreotide scintigraphy.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 48 (2), 120-124, 2008

    Societas Neurologica Japonica

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