シンポジウム１２‐３ 神経疾患の臨床研究を目指したコンソーシアム Ｊａｐａｎｅｓｅ Ｃｏｎｓｏｒｔｉｕｍ ｆｏｒ Ａｍｙｏｔｒｏｐｈｉｃ Ｌａｔｅｒａｌ Ｓｃｌｅｒｏｓｉｓ Ｒｅｓｅａｒｃｈ（ＪａＣＡＬＳ）
書誌事項
- タイトル別名
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- Japanese consortium for amyotrophic lateral sclerosis research (JaCALS)
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説明
To investigate the longitudinal course of Japanese patients with Amyotrophic Lateral Sclerosis (ALS), we constructed a multicenter registration and follow-up system called Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS). Genomic DNA samples of ALS patients were stored and linked to the clinical information. We designed a telephone survey system using a clinical research coordinator (CRC) to check the score of the ALS Functional Rating Scale-R (ALSFRS-R) and the prognosis every 3 months. In January 2006, we began registering ALS patients, and, at present, 19 neurology facilities are participating in the JaCALS. Currently, 421 Japanese ALS patients are registered. The longitudinal courses and prognoses of 93% of the 284 patients over a year from registration have been recorded in this system. In collaboration with the RIKEN Center for Genomic Medicine, genome-wide association studies (GWAS) for ALS susceptibility genes were conducted using 981 ALS samples from the JaCALS and BioBank Japan. Novel associated genes were identified, and replication studies are underway.<br> JaCALS has established an efficient registration and follow-up system with genomic DNA resources of ALS patients, and will contribute to identify ALS-associated genes and to promote clinical researches. <br>
収録刊行物
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- 臨床神経学
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臨床神経学 50 (11), 928-930, 2010
日本神経学会
