Prognostic significance of tryptophan catabolism in adult T-cell leukemia/lymphoma
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- MASAKI Ayako
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences
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- ISHIDA Takashi
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- MAEDA Yasuhiro
- Laboratory of Hospital Pharmacy, Nagoya City University Graduate School of Pharmaceutical Sciences
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- SUZUKI Susumu
- Department of Tumor Immunology, Aichi Medical University School of Medicine
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- ITO Asahi
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- TAKINO Hisashi
- Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences
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- TOTANI Haruhito
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- YOSHIDA Takashi
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- KINOSHITA Shiori
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- OGURA Hiroka
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- NARITA Tomoko
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- RI Masaki
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- KUSUMOTO Shigeru
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- INAGAKI Atsushi
- Department of Hematology and Oncology, Nagoya City West Medical Center
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- KOMATSU Hirokazu
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
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- NIIMI Akio
- Department of Respiratory Medicine, Allergy and Rheumatology, Nagoya City University Graduate School of Medical Sciences
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- UEDA Ryuzo
- Department of Tumor Immunology, Aichi Medical University School of Medicine
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- UTSUNOMIYA Atae
- Department of Hematology, Imamura Bun-in Hospital
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- INAGAKI Hiroshi
- Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences
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- IIDA Shinsuke
- Department of Hematology & Oncology, Nagoya City University Graduate School of Medical Sciences
Bibliographic Information
- Other Title
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- 成人T細胞白血病/リンパ腫におけるトリプトファン代謝の予後に関する意義
- セイジン Tサイボウ ハッケツビョウ/リンパシュ ニ オケル トリプトファン タイシャ ノ ヨゴ ニ カンスル イギ
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Abstract
Purpose: Indoleamine 2,3-dioxygenase 1 (IDO1: IDO) is an enzyme catabolizing tryptophan (Trp) into the kynurenine (Kyn) pathway, and is an important micro-environmental factor suppressing antitumor immune responses. We investigated the prognostic significance of Trp catabolism in adult T-cell leukemia/lymphoma (ATL). Experimental Design: We quantified serum Trp and Kyn in 96 ATL patients, 38 human T-cell lymphotropic virus type-1 asymptomatic carriers (HTLV-1 ACs), and 40 healthy adult volunteers. The relationships between various clinical parameters were analyzed. IDO expression was evaluated in the affected lymph nodes of ATL patients. Results: Serum Kyn concentrations and Kyn/Trp ratios were significantly higher in HTLV-1 ACs than in healthy controls. Both increased significantly with progression from HTLV-1 AC to ATL. There were no significant differences in serum Trp concentrations between ATL patients, HTLV-1 ACs and controls. IDO was possibly produced by ATL and/or cells in the microenvironment. Multivariate analyses demonstrated a high serum Kyn/Trp ratio and high Kyn level, but not a high Trp level, to be significant independent detrimental prognostic factors in ATL and aggressive variant ATL. Conclusions: Quantification of serum Kyn and Trp is prognostically useful for individual ATL patients. Furthermore, ATL is an appropriate disease for testing novel cancer immunotherapies targeting IDO.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 56 (11), 2295-2304, 2015
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390001205037474560
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- NII Article ID
- 130005130183
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 026962484
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- PubMed
- 26666715
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed