Effects of Nerve Stimulation and Drugs on the Release of Histamine and Norepinephrine from the Isolated Heart
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- HARVEY Stewart C.
- Department of Pharmacology, University of Utah College of Medicine
Bibliographic Information
- Other Title
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- Effects of Nerve Stimulation and Drugs
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Abstract
Compound 48/80 and Polymyxin B elicited prompt and sharp increases in histamine output from the isolated guinea pig heart and had no effect on norepinephrine output. Dextran decreased histamine output without affecting norepinephrine output. Bradykinin increased both histamine and norepinephrine output; the histamine output increased only after a latent period. Stimulation of both left and right stellate ganglia increased norepinephrine output, but only right ganglion stimulation increased histamine output, after a latency. Stimulation of the right but not the left vagus nerve decreased histamine output first, then increased it moderately, the peak of which came later than norepinephrine release. It was suggested that histamine release following nerve stimulation and bradykinin was secondary to norepinephrine release. Isoniazid decreased the output of both histamine and norepinephrine. Aminoguanidine increased histamine output but decreased norepinephrine output.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 20 (2), 183-193, 1979
International Heart Journal Association
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Details 詳細情報について
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- CRID
- 1390001205037624576
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- NII Article ID
- 130000762194
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- NII Book ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 2081765
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- PubMed
- 87528
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed