The Effect of Thyroxine on (Na+,K+)-ATPase from the Heart and the Kidney of Rabbit
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- SHIMADA Kazuyuki
- Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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- YAZAKI Yoshio
- Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
書誌事項
- タイトル別名
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- The Effect of Thyroxine on (Na<sup>+</sup>, K<sup>+</sup>)-ATPase from the Heart and the Kidney of Rabbit
- Effect of Thyroxine on Na + K + ATPase
この論文をさがす
抄録
The effect of thyroxine on membrane bound (Na+, K+)-ATPase isolated as a microsomal fraction from rabbit heart and kidney was investigated. In the heart, thyroxine administration produced an increased Ki value (a concentration of ouabain required for half maximal inhibition of (Na+, K+)-ATPase activity) without alteration of the specific activity of cardiac (Na+, K+)-ATPase, indicating that the digitalis sensitivity of cardiac (Na+, K+)-ATPase was decreased. On the contrary, a significant increase of the specific activity of renal (Na+, K+)-ATPase was observed without change in its digitalis sensitivity. These results suggest that (1) a decreased sensitivity of cardiac (Na+, K+)-ATPase to digitalis glycosides in thyrotoxic animals may contribute to the decrease in the inotropic and toxic effects of the digitalis glycosides in the hyperthyroid state, and that (2) there may be an organ difference in (Na+, K+)ATPase.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 19 (5), 754-761, 1978
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205037649920
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- NII論文ID
- 130000762449
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2073438
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- PubMed
- 215798
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可