The Effect of Thyroxine on (Na<sup>+</sup>, K<sup>+</sup>)-ATPase from the Heart and the Kidney of Rabbit
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- SHIMADA Kazuyuki
- Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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- YAZAKI Yoshio
- Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- The Effect of Thyroxine on (Na+,K+)-ATPase from the Heart and the Kidney of Rabbit
- Effect of Thyroxine on Na + K + ATPase
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Abstract
The effect of thyroxine on membrane bound (Na+, K+)-ATPase isolated as a microsomal fraction from rabbit heart and kidney was investigated. In the heart, thyroxine administration produced an increased Ki value (a concentration of ouabain required for half maximal inhibition of (Na+, K+)-ATPase activity) without alteration of the specific activity of cardiac (Na+, K+)-ATPase, indicating that the digitalis sensitivity of cardiac (Na+, K+)-ATPase was decreased. On the contrary, a significant increase of the specific activity of renal (Na+, K+)-ATPase was observed without change in its digitalis sensitivity. These results suggest that (1) a decreased sensitivity of cardiac (Na+, K+)-ATPase to digitalis glycosides in thyrotoxic animals may contribute to the decrease in the inotropic and toxic effects of the digitalis glycosides in the hyperthyroid state, and that (2) there may be an organ difference in (Na+, K+)ATPase.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 19 (5), 754-761, 1978
International Heart Journal Association
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Details 詳細情報について
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- CRID
- 1390001205037649920
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- NII Article ID
- 130000762449
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- NII Book ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 2073438
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- PubMed
- 215798
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed