Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardial Lesion
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- HIGUCHI Makie
- Department of Pharmacology, Kumamoto University Medical School
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- TAKENAKA Fumio
- Department of Pharmacology, Kumamoto University Medical School
Bibliographic Information
- Other Title
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- Effect of Verapamil on the Transmural Energy Metabolism in the Isoproterenol-induced Myocardinal Lesion
- Effect of Verapamil on the Transmural E
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Abstract
The effect of verapamil on the isoproterenol(ISO)-induced transmural metabolic lesion in the left ventricular wall was investigated in the rat heart. The treatment with ISO 2.5mg/Kg s.c. on 2 consecutive days resulted in significant decreases of creatine phosphate in the subendocardium(ENDO) and of adenosine triphosphate in the ENDO and the subepicardium. On the other hand, inorganic phosphate(Pi) and lactate (LA) were increased in both layers. These changes were more prominent in the ENDO. Pretreatment with verapamil 25mg/Kg s.c. prevented the reduction of high energy phosphate compounds and the increases of Pi and LA in both layers by ISO.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 19 (6), 913-917, 1978
International Heart Journal Association
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Details 詳細情報について
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- CRID
- 1390001205037662464
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- NII Article ID
- 130000762465
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- NII Book ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 2074108
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- PubMed
- 750673
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed