Effects of Beta-Adrenergic Blocking Drug Pindolol (LB46) on Cardiac Fibers in Relation to Its Membrane Effects
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- SHIMIZU Takeshi
- Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University
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- IWAMURA Nobuyuki
- Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University
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- KODAMA Itsuo
- Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University
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- TOYAMA Junji
- Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University
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- YAMADA Kazuo
- Department of Circulation and Respiration, Research Institute of Environmental Medicine, Nagoya University
書誌事項
- タイトル別名
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- Effects of Beta Adrenergic Blocking Dru
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抄録
Direct membrane effects and beta-adrenergic blocking action of pindolol were studied comparatively on isolated perfused cardiac fibers of dogs. In Purkinje fibers, the duration of transmembrane action potential decreased in concentrations higher than 0.5mg/L. Maximum rate of depolarization also decreased in higher concentrations (5.0mg/L or more). The functional refractory period decreased to a lesser degree compared with the decrease of the action potential duration. Nevertheless, slowrising action potentials could not be abolished in premature responses, probably because of membrane depressant effects, of this drug. In ventricular muscle fibers, these changes were minimum in the same range of concentrations. On the other hand, 0.05mg/L of pindolol which was close to the therapeutic plasma concentrations and had no effect on action potentials of both Purkinje and ventricular muscle fibers, minimized the increase in automaticity of Purkinje fibers induced by 0.2mg/L of isoproterenol. It is rationally speculated that the mechanism of antiarrhthmic action of pindolol is mainly due to its beta-adrenergic blocking action.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 19 (6), 865-876, 1978
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205037664640
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- NII論文ID
- 130000762460
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2074120
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- PubMed
- 750670
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可