Effects of Anti-Anginal Agents on Cyclical Reductions of Coronary Blood Flow

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  • UCHIDA Yasumi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • YOSHIMOTO Nobuo
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • MURAO Satoru
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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  • Effects of Anti Anginal Agents on Cycli

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Abstract

The effects of coronary vasodilating agents and alpha- and beta-adrenergic blocking agents on cyclical reductions of blood flow in the partially constricted coronary artery of anesthetized dogs were examined. Intravenous injections of nitroglycerin (50μg/Kg), SG 75 (150μg/Kg), papaverine (1mg/Kg), and nicotinic acid (10mg/Kg) eliminated both cyclical reductions of flow and ST elevation (group 1). Nifedipine (10μg/Kg), verapamil (500μg/Kg), diltiazem (500μg/Kg), and propranolol (500μg/Kg) suppressed ST elevation, but they could not eliminate cyclical reductions of flow (group 2). Dipyridamole (1mg/Kg) and phentolamine (500μg/Kg) augmented both ST elevation and cyclical reductions of flow (group 3). The results indicate that ST elevation due to cyclical reductions of coronary blood flow was eliminated by spasmolytic actions of group 1 on coronary artery, was suppressed by negative chronotropic and/ or inotropic actions of group 2, and was augmented by peripheral actions of group 3.

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