Creatine Kinase-MB Protein Mass Is a Better Indicator for the Assessment of Acute Myocardial Infarction in the Lower Range of Creatine Kinase Level.

DOI Web Site PubMed オープンアクセス

この論文をさがす

説明

The theoretical and clinical validity of immunochemiluminometric assay of creatine kinase (CK)-MB protein mass was assessed in patients with acute myocardial infarction and the results were compared with those of immunoinhibition assay of CK activity. Serial changes of both CK-MB protein mass and CK-MB activity were analyzed in 20 consecutive patients. In all 312 samples from 20 patients, protein mass and activity of CK-MB showed good correlation. The exponential fitting of the time-value curve of CK-MB protein mass showed a better correlation coefficient than that of CK-MB activity (0.97±0.02 vs 0.93±0.07, p<0.05), indicating that the CK-MB level measured by the immunochemiluminometric assay was less scattered than that measured by the immunoinhibition method. This finding was most evident at lower CK-MB values (<500IU/l). The rate of disappearance from serum of CK-MB protein mass was faster than that of CK-MB activity (0.54±0.23hr-1 vs 0.28±0.13hr-1, p<0.001). This may indicate that some amount of the CK-MB activity may be inactivated in the early phase of the release into the serum from the necrotic myocardium.<br>Thus, the immunochemiluminometric assay of CK-MB protein mass has superiority in the diagnosis of acute myocardial infarction compared with the immunoinhibition method, especially when the measured CK-MB level is low. This feature may be useful to distinguish a small myocardial infarction from severe ischemia without myocardial necrosis.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ