Hypotensive Action and Increased Plasma Renin Activity by Ca<sup>2+</sup> Antagonist (Nifedipine) in Hypertensive Patients
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- AOKI Kyuzo
- Second Department of Medicine, Nagoya City University Medical School
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- YOSHIDA Tadashi
- Second Department of Medicine, Nagoya City University Medical School
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- KATO Setsuko
- Second Department of Medicine, Nagoya City University Medical School
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- TAZUMI Kazuhiro
- Second Department of Medicine, Nagoya City University Medical School
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- SATO Iwao
- Second Department of Medicine, Nagoya City University Medical School
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- TAKIKAWA Kiyoharu
- Second Department of Medicine, Nagoya City University Medical School
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- HOTTA Ken
- First Department of Physiology, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- Hypotensive action and increased plasma renin activity by Ca2+ anatagonist(Nifedipine)in hypertensive patients
- Hypotensive action and increased plasma
- Hypertensive action and increased plasma renin activity by Ca antagonist (nifedipine) in hypertensive patients
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Abstract
The Ca2+ antagonistic coronary vasodilator, Nifedipine, was sublingually administered by a dose of 30mg to 19 patients with hypertension.<br>Blood pressure of patients with essential hypertension (n=14) decreased from 177±24 to 123±13mmHg systolic and from 108±12 to 80±11mmHg diastolic (mean±SD) (p<0.01). Heart rate increased significantly from 73±11 to 85±10 beats/min (p<0.01). Plasma renin activity (PRA) increased significantly from 0.73±0.62 to 1.50±1.02ng/ml/h (p<0.05). The same tendency was observed in malignant and renovascular hypertension. In primary aldosteronism (n=2), blood pressure decreased but PRA did not increase.<br>Hypotensive action and increased plasma renin activity by Ca2+ antagonist, Nifedipine, were clearly demonstrated in patients with hypertension.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 17 (4), 479-484, 1976
International Heart Journal Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001205038881536
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- NII Article ID
- 130000763364
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- NII Book ID
- AA00690786
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- COI
- 1:STN:280:CSiD3cbjvVY%3D
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 1718248
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- PubMed
- 966384
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed