Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
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- KOBAYASHI Miyoharu
- Department of Pharmacology, Faculty of Medicine, Shinshu University
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- FURUKAWA Yasuyuki
- Department of Pharmacology, Faculty of Medicine, Shinshu University
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- CHIBA Shigetoshi
- Department of Pharmacology, Faculty of Medicine, Shinshu University
書誌事項
- タイトル別名
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- Absence of Acute Cardiac Effect of Trii
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Effects of triiodothyronine (T3) on SA node pacemaker activity, atrial contractility and on chronotropic and inotropic responses to norepinephrine were investigated, using 9 isolated, blood-perfused dog atrium preparations. T3 (0.001pg-0.1μg) did not cause a significant direct action injected into the cannulated sinus node artery. When T3 (10pg/min, 40pg/min, 0.1μg/min, or 0.4μg/min) was continuously infused into the sinus node artery, both positive chronotropic and inotropic actions of norepinephrine (0.03μg-0.3μg) were not influenced.<br>From these results, it is concluded that T3 has neither acutely direct chronotropic nor inotropic effects, and also T3 does not have an acute effect on responses to norepinephrine in the isolated, blood-perfused canine atrium.
収録刊行物
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- Ｊａｐａｎｅｓｅ Ｈｅａｒｔ Ｊｏｕｒｎａｌ
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Ｊａｐａｎｅｓｅ Ｈｅａｒｔ Ｊｏｕｒｎａｌ 20 (2), 219-226, 1979
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205038962048
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- NII論文ID
- 130000762197
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2081763
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- PubMed
- 449053
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可