Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium

DOI Web Site Web Site PubMed

書誌事項

タイトル別名
  • Absence of Acute Cardiac Effect of Trii

この論文をさがす

抄録

Effects of triiodothyronine (T3) on SA node pacemaker activity, atrial contractility and on chronotropic and inotropic responses to norepinephrine were investigated, using 9 isolated, blood-perfused dog atrium preparations. T3 (0.001pg-0.1μg) did not cause a significant direct action injected into the cannulated sinus node artery. When T3 (10pg/min, 40pg/min, 0.1μg/min, or 0.4μg/min) was continuously infused into the sinus node artery, both positive chronotropic and inotropic actions of norepinephrine (0.03μg-0.3μg) were not influenced.<br>From these results, it is concluded that T3 has neither acutely direct chronotropic nor inotropic effects, and also T3 does not have an acute effect on responses to norepinephrine in the isolated, blood-perfused canine atrium.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ