Effects of Bucumolol,a β-Adrenergic Blocking Agent,and Its d-Isomer on Myocardial Infarction Produced by Coronary Artery Ligation in Rats
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- KOIKE Hiroyuki
- Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
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- KUMAKURA Seiji
- Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
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- NISHINO Hiroshi
- Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
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- TAMAOKI Hidetsune
- Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
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- MINATO Sadamasa
- Cardiovascular Division, Central Research Laboratories and Fermentation Research Laboratories, Sankyo Co., Ltd.
書誌事項
- タイトル別名
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- Effects of bucumolol, a .BETA.-adrenergic blocking agent, and its d-isomer on myocardical infarction produced by coronary artery ligation in rats.
- Effects of Bucumolol a ベータ Adrenergic B
この論文をさがす
抄録
Acute ligation of the left coronary artery of rats produced abnormal Q-wave in the electrocardiogram, tachycardia and frequent ventricular fibrillation. Serum CPK level was elevated, reaching a maximum at 3 to 5 hours after ligation and returning to near the pre-ligation level 24 hours later, when CPK activity in the left ventricle markedly decreased. Pretreatment with bucumolol at 2.5mg/Kg s.c. and 5mg/Kg s.c. lessened these changes and increased the survival rate in a dose related manner. d-Bucumolol at 5mg/Kg, on the other hand, increased survival rate primarily by suppressing ventricular fibrillation without any significant effect on other parameters. These results suggest that the membrane stabilizing action does not contribute to protective actions of bucumolol against myocardial ischemia.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 22 (5), 815-823, 1981
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205039276160
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- NII論文ID
- 130000763830
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- NII書誌ID
- AA00690786
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- ISSN
- 1348673X
- 00214868
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- NDL書誌ID
- 2474736
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- PubMed
- 6119377
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可