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Clinical, epidemiological, and etiological studies of adult aseptic meningitis: a report of 12 cases of herpes simplex meningitis, and a comparison with cases of herpes simplex encephalitis
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- Himeno Takahiro
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
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- Shiga Yuji
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital Present address: Hiroshima University Graduate School of Biomedical and Health Sciences
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- Takeshima Shinichi
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital Present address: Showa University School of Medicine
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- Tachiyama Keisuke
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital Present address: Hiroshima City Hiroshima Citizens Hospital
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- Kamimura Teppei
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital Present address: National Central and Cardiovascular Center
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- Kono Ryuhei
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
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- Takemaru Makoto
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
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- Takeshita Jun
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
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- Shimoe Yutaka
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
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- Kuriyama Masaru
- Department of Neurology, Brain Attack Center, Ota Memorial Hospital
Bibliographic Information
- Other Title
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- 成人無菌性髄膜炎の臨床的検討（第4報）―単純ヘルペス髄膜炎12例について，および単純ヘルペス脳炎との比較を含め―
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Description
<p>We treated 437 cases of adult aseptic meningitis and 12 cases (including 2 recurrent patients; age, 31.8 ± 8.9 years; 7 females) of herpes simplex meningitis from 2004 to 2016. The incidence rate of adult herpes simplex meningitis in the cases with aseptic meningitis was 2.7%. One patient was admitted during treatment of genital herpes, but no association was observed between genital herpes and herpes simplex meningitis in the other cases. The diagnoses were confirmed in all cases as the cerebrospinal fluid (CSF) was positive for herpes simplex virus (HSV)-DNA. For diagnosis confirmation, the DNA test was useful after 2–7 days following initial disease onset. Among other types of aseptic meningitis, the patients with herpes simplex meningitis showed relatively high white blood cell counts and relatively high CSF protein and high CSF cell counts. CSF cells showed mononuclear cell dominance from the initial stage of the disease. During same period, we also experienced 12 cases of herpes simplex encephalitis and 21 cases of non-hepatic acute limbic encephalitis. Notably, the patients with herpes simplex meningitis were younger and their CSF protein and cells counts were higher than those of the patients with herpes simplex encephalitis.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 58 (1), 1-8, 2018
Societas Neurologica Japonica