Effects of Left Atrial Pressure and Myocardial Contractility on Left Ventricular Volumes

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  • KAMIYA Akira
    Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
  • TOGAWA Tatsuo
    Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

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The effects of left atrial pressure and myocardial contractility on left ventricular stroke volume (SV), end-diastolic volume (EDV) and end-systolic volume (ESV) were investigated. The left ventricular volumes of dogs were measured by means of thermo-dilution with a thermistor of which time constant was very short (<0.05sec.). Ejected fractions measured in the experiments were averaged 0.50. The recordings were repeated on the 2 experimental conditions of cotrol and elevated left atrial pressure with fixed stimulation of stellate ganglion and cotrol and increased sympathetic stimulation with fixed left atrial pressure, where heart rates and arterial pressure were held constant. The results showed the close correlations only between left atrial pressure and EDV and between sympathetic stimulation and ESV. For elevation of left atrial pressure, the ratio of changes of EDV and ESV (ΔEDV/ΔESV) was about 4.1 which means that increase of SV in this case is chiefly due to increase of EDV. For increased sympathetic stimulation, ΔEDV/ΔESV was about 0.03 which means that increase of SV in this case is chiefly due to decrease of ESV.

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