Anti-CD2 Monoclonal Antibodies Prevent the Induction of Experimental Autoimmune Myocarditis.
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抄録
We investigated the effect of a monoclonal antibody against CD2 molecules (OX34) in preventing the induction of experimental autoimmune myocarditis (EAM) induced by immunizing Lewis rats with cardiac myosin. Administration of OX34 before immunization, on Days -6, -4, -2 and 0, completely prevented EAM. On the other hand, treatment with OX34 just before the appearance of myocardial lesions, on Days 9, 11, 13 and 15, had only a partial effect in preventing the disease. Flow cytometric analysis of lymph node cells showed that CD3+ T cells were immediately depleted with the administration of OX34 but had largely recovered on Day 21. Lymph node cells in OX34-treated rats had no proliferative responses to cardiac myosin-rod, but the proliferation was restored when recombinant IL-2 was added. Ultimate production of the anti-myosin antibody was not inhibited by the treatment with OX34. These results suggest that the prevention of EAM by administering the anti-CD2 monoclonal antibody OX34 resulted from T cell depletion during the induction phase, and might in addition result from T cell anergy of Th1, but not Th2 cells.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 41 (4), 507-517, 2000
International Heart Journal刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001205039844224
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- NII論文ID
- 130000070626
- 30010197518
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- NII書誌ID
- AA00690786
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- COI
- 1:CAS:528:DC%2BD3cXnsF2nsrw%3D
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- ISSN
- 1348673X
- 00214868
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- PubMed
- 11041101
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可