Constant infusion of hypertonic saline in the dog-3-Effects of physiologic saline preloading and of aldosterone thereon

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  • NAGASAKA Masahito
    First Department of Medicine, Faculty of Medicine, University of Tokyo
  • NAKAMURA Kazumichi
    First Department of Medicine, Faculty of Medicine, University of Tokyo
  • KINOUCHI Takashi
    First Department of Medicine, Faculty of Medicine, University of Tokyo
  • ITO Teizo
    First Department of Medicine, Faculty of Medicine, University of Tokyo
  • TAKAHASHI Masao
    First Department of Medicine, Faculty of Medicine, University of Tokyo
  • YOSHITOSHI Yawara
    First Department of Medicine, Faculty of Medicine, University of Tokyo

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タイトル別名
  • Constant Infusion of Hypertonic Saline in the Dog
  • III. Effects of Physiologic Saline Preloading and of Aldosterone Thereon

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The characteristic values of renal Na regulatory system were determined during constant infusion experiment of hypertonic saline with and without physiological saline preloading. After physiological saline preloading renal threshold for Na rejection was lowered significantly. Aldosterone could not counteract this lowering of renal Na threshold. It is inferred that Na excretion after elevation of plasma Na concentration is linearly dependent on its concentration under both conditions with and without physiological salin epreloading. This finding is consistent with the single capacitive model of the first report. And aldosterone cannot control augmented overflowing Na rejection induced by conditioning volume and Na preload. This supports the dualistic concept in the renal Na reabsorptive mechanism.

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