Epinephrine-Induced Pulmonary Edema in Crosscirculated Animals

  • WORTHEN M.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences
  • ARGANO B.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences
  • SIWADLOWSKI W.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences
  • BRUCE D.W.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences
  • MACCANON D.M.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences
  • LUISADA A.A.
    Division of Cardiovascular Research of The Chicago Medical School, University of Health Sciences

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抄録

Blood with epinephrine was infused into crosscirculated dogs and comparison was made between animals receiving the infusion only in their heads, only in their trunks, or in their entire circulation.<br>The procedure was invariably followed by pulmonary edema in all experimental animals.<br>Left ventricular systolic pressure elevations and increases of the dp/dt of this chamber were similar in all animals irrespective of the area infused. Left ventricular end-diastolic pressure elevations also occurred in all animals but were greater in the "trunk dogs" than in the "head dogs" or the "whole dogs".<br>These results suggest that both neurogenic stimuli and circulating catecholamines (either injected or secreted under the influence of nerve stimulation) contribute to the chain of events leading to formation of pulmonary edema.

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