Activation of Electrogenic Na<sup>+</sup> Pump by Epinephrine in Bullfrog Atrium
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- AKASU Takashi
- Department of Physiology, Kurume University School of Medicine
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- OHTA Yhukou
- Department of Physiology, Kurume University School of Medicine
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- KOKETSU Kyozo
- Department of Physiology, Kurume University School of Medicine
Bibliographic Information
- Other Title
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- Activation of Electrogenic Na+ Pump by Epinephrine in Bullfrog Atrium
- Activation of Electrogenic Na + Pump by
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Abstract
The effects of epinephrine (1×10-6-1×10-5M) on the resting membrane potential and the K+-activated hyperpolarization of bullfrog atrial heart muscles were studied by the single sucrose-gap method or by intracellular microelectrode filled with 3M KCl. Epinephrine-induced hyperpolarization (Ep-hyperpolarization) was completely eliminated by the effect of ouabain or by removal of extracellular K+. The amplitude of K+-activated hyperpolarization, which was produced when the extracellular K+ concentration was raised from zero to 2mM, was markedly increased in the presence of epinephrine. The membrane depolarizations, due to high extracellular K+ concentration in the presence of ouabain (5×10-6M) which completely and reversibly eliminated the K+-activated hyperpolarization, were not altered under the effect of epinephrine.<br>These results suggested that Ep-hyperpolarization of bullfrog atrial heart muscles was due to the acceleration of electrogenic Na+ pump which produced the K+-activated hyperpolarization.
Journal
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- Japanese Heart Journal
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Japanese Heart Journal 18 (6), 860-866, 1977
International Heart Journal Association
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Details 詳細情報について
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- CRID
- 1390001205040016768
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- NII Article ID
- 130000762893
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- NII Book ID
- AA00690786
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- COI
- 1:CAS:528:DyaE1cXksFekur0%3D
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- ISSN
- 1348673X
- 00214868
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- NDL BIB ID
- 1914753
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- PubMed
- 304908
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed