Physiological Difference between Dietary Obesity-Susceptible and Obesity-Resistant Sprague Dawley Rats in Response to Moderate High Fat Diet.
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- JANG InSurk
- Department of Animal Science & Biotechnology, RAIRC, Jinju National University
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- HWANG DaeYeon
- Laboratory Animal Resources, National Institute of Toxicological Research
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- LEE JuEun
- Laboratory Animal Resources, National Institute of Toxicological Research
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- CHAE KabRyong
- Laboratory Animal Resources, National Institute of Toxicological Research
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- KIM YongKyu
- Laboratory Animal Resources, National Institute of Toxicological Research
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- KANG TaeSeok
- Laboratory Animal Resources, National Institute of Toxicological Research
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- KIM ChulKyu
- Laboratory Animal Resources, National Institute of Toxicological Research
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- SHIN DongHwan
- Laboratory Animal Resources, National Institute of Toxicological Research
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- HWANG JinHee
- Laboratory Animal Resources, National Institute of Toxicological Research
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- HUH YoungBuhm
- Department of Anatomy, College of Medicine, Kyunghee University
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- CHO JungSik
- Laboratory Animal Resources, National Institute of Toxicological Research
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説明
The primary aim of the present study was to define central and peripheral physiological differences between dietary obesity-susceptible (DOS) and obesity-resistant (DOR) outbred Sprague Dawley (SD) rats when given a moderate high fat diet containing 32.34% of energy as a fat. After a 9-week feeding period, the DOS-SD rats consumed significantly more feed (11.1%) and had higher abdominal (39.9%) and epididymal (27.5%) fat pads than the DOR-SD rats. In addition, serum leptin and insulin levels were significantly increased in the DOS-SD rats compared with those in the DOR-SD rats. However, we did not observe significant differences in serum triglyceride, cholesterol and glucose. No differences in hypothalamic OB-Ra and Rb mRNA expressions were found between the two groups. In contrast, arcuate NPY immunohistochemical expression was much higher in the DOS-SD rats than in the DOR-SD rats, though NPY expression in the supraoptic and paraventricular nuclei was not different between the two phenotypes. In peripheral tissues, the DOS-SD rats showed noticeably increased acetyl CoA carboxylase (ACC) mRNA expression in the liver, not epididymal fat. However, Western blot of peroxisomal proliferator activated factor γ (PPARγ) in the liver and epididymal fat was not different between the two phenotypes of SD rats. It was concluded that different body weight phenotypes within outbred SD population responded differently to the development of dietary induced obesity via altered anabolic features in the hypothalamus and liver.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 52 (2), 99-107, 2003
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205040782848
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- NII論文ID
- 130000068465
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 6507763
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- PubMed
- 12806884
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可