The Effect of cAMP on Electrogenic Na+ Absorption in the Rat Distal Colon.
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- Tsuchiya Yo
- Laboratory of Physiology, School of Food and Nutritional Sciences, University of Shizuoka
書誌事項
- タイトル別名
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- Effect of cAMP on Electrogenic Na Absorption in the Rat Distal Colon
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抄録
Cyclic AMP is a ubiquitous second messenger produced in cells in response to extracellular stimulants. The aim of this study was to examine its role in the regulation of amiloride-sensitive electrogenic Na+ absorption in the rat distal colon by measuring the short-circuit current (Isc) and 22Na+ fluxes in a chamber-mounted mucosal sheet. Forskolin stimulated the amiloride-inhibitable Isc and amiloride-inhibitable 22Na+ absorption. 8Br-cAMP also stimulated the amiloride-inhibitable Isc. Furthermore, isoproterenol, acting via β-adrenergic activation, stimulated the amiloride-inhibitable Isc. The isoproterenol-induced increase in the amiloride-sensitive Isc was largely suppressed by H89, a protein kinase A inhibitor. In conclusion, cAMP can upregulate amiloride-sensitive electrogenic Na+ absorption in the rat distal colon.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 51 (4), 435-444, 2001
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205040935552
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- NII論文ID
- 130004435775
- 50000944437
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD3MXntlahsLY%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 5907118
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- PubMed
- 11564280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可