Sequence Analysis of Major Structural Proteins of Newly Isolated Mouse Hepatitis Virus.

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  • YAMADA Yasuko K.
    Division of Experimental Animal Research, National Institute of Infectious Diseases
  • YABE Mikiko
    Division of Experimental Animal Research, National Institute of Infectious Diseases

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We have isolated the virus from a fecal pellet in the colon of a BALB/c mouse with X-linked immunodeficiency (xid) housed in a room in which there has recently been an epidemic due to mouse hepatitis virus (MHV) and designated it as the MHV-TY strain. Sequence analysis of the MHV-TY strain was performed on major structural, spike (S), membrane (M) and nucleocapsid (N), proteins directly from PCR products. The comparison of nucleotide sequences of MHV-TY with other strains investigated so far revealed that all three structural proteins of the TY strain had some unique amino acid sequences among MHV strains which can be used as markers of this strain.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 49 (1), 61-66, 2000

    公益社団法人 日本実験動物学会

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