Variable Unstressed Volume Keeps Normal Distributions of Canine Left Ventricular Contractility and Total Mechanical Energy under Atrial Fibrillation
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- Mohri Satoshi
- Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Shimizu Juichiro
- Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Physiology II, Nara Medical University
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- Ito Haruo
- Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Physiology II, Nara Medical University
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- Yamaguchi Hiroki
- Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Sano Shunji
- Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- Takaki Miyako
- Department of Physiology II, Nara Medical University
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- Suga Hiroyuki
- Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences National Cardiovascular Center Research Institute
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We have reported that the contractility index (Emax) and the total mechanical energy (PVA) of arrhythmic beats of the left ventricle (LV) distribute normally in canine hearts under electrically induced atrial fibrillation (AF). Here, Emax is the ventricular elastance as the slope of the end-systolic (ES) pressure-volume (P-V) relation (ESPVR), and PVA is the systolic P-V area as the sum of the external mechanical work within the P-V loop and the elastic potential energy under the ESPVR. To obtain Emax and PVA, we had to assume the systolic unstressed volume (Vo) as the V-axis intercept of the ESPVR to be constant despite the varying Emax, since there was no method to obtain Vo directly in each arrhythmic beat. However, we know that in regular stable beats Vo decreases by ∼7 ml/100 g LV with ∼100 times the increases in Emax from ∼0.2 mmHg/(ml/100 g LV) of almost arresting weak beats to ∼20 mmHg/(ml/100 g LV) of strong beats with a highly enhanced contractility. In the present study, we investigated whether Emax and PVA under AF could still distribute normally, despite such Emax-dependent Vo changes. The present analyses showed that the Emax changes were only ∼3 times at most from the weakest to the strongest arrhythmic beat under AF. These changes were not large enough to affect Vo enough to distort the frequency distributions of Emax and PVA from normality. We conclude that one could practically ignore the slight Emax and PVA changes with the Emax-dependent Vo changes under AF.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 55 (5), 255-264, 2005
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205041166976
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- NII論文ID
- 10018623883
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- NII書誌ID
- AA00691224
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 7836830
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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