Oxygen Costs of Left Ventricular Contractility for Dobutamine and Ca〔2+〕 in Normal Rat Hearts and the Cost for Dobutamine in Ca〔2+〕 Overload-Induced Failing Hearts
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- Tabayashi Nobuoki
- Departments of Surgery III and Physiology II, Nara Medical University
書誌事項
- タイトル別名
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- Oxygen Costs of Left Ventricular Contractility for Dobutamine and Ca2+ in Normal Rat Hearts and the Cost for Dobutamine in Ca2+ Overload-Induced Failing Hearts.
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説明
The aim of the present study was to compare the oxygen (O2) cost of left ventricular (LV) contractility (equivalent maximal elastance; eEmax, an index for contractility) for dobutamine (a β-receptor stimulant) with that for calcium (Ca2+) in normal rat hearts and to assess the O2 cost of LV eEmax for dobutamine in Ca2+ overload-induced failing rat hearts. The mean O2 cost of LV eEmax (×10−4 μl O2·beat−1·mmHg−1·ml·g−2) for Ca2+ was 1.30±0.37 in 12 normal hearts, and for dobutamine it was 1.26±0.30 in eight different normal hearts. In the same five normal hearts, the mean O2 cost of LV eEmax for dobutamine was 1.15±0.27, and for Ca2+ it was 0.81±0.36. These mean values showed no significant differences between Ca2+ and dobutamine. In five Ca2+ overload-induced failing hearts, the mean O2 cost of LV eEmax for Ca2+ could not be assessed, but the mean O2 cost of LV eEmax for dobutamine was 1.04±0.40. This mean value for dobutamine did not differ significantly from those (see above 1.26±0.30 or 1.15±0.27) in the normal hearts. The present results indicate, in terms of the coupling of mechanical work and energetics of the heart, that the total Ca2+ handling VO2 in excitation-contraction coupling against unit LV contractility change for dobutamine in the contractile failing hearts does not differ from that in the normal hearts. This suggests that in the Ca2+ overload-induced contractile failing hearts, there were no changes in the sensitivity of the contractile machinery for Ca2+, in the Ca2+/ATP in the total Ca2+ handling, and in the ATP/VO2 in the mitochondria.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 52 (2), 163-171, 2002
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205041279488
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- NII論文ID
- 10009505587
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD38Xmt1ait7w%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 6228904
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- PubMed
- 12139774
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
