Threshold Changes in Auditory Brainstem Response(ABR) Due to the Administration of Kanamycin in Dogs.

DOI Web Site Web Site PubMed 被引用文献2件 参考文献28件
  • UZUKA Yuji
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • FURUTA Tomohiro
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • YAMAOKA Mayumi
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • OHNISHI Takafumi
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
  • TSUBONE Hirokazu
    Laboratory of Veterinary Pathophysiology, Faculty of Agriculture, Tokyo University
  • SUGANO Shigeru
    Laboratory of Veterinary Pathophysiology, Faculty of Agriculture, Tokyo University

書誌事項

タイトル別名
  • Threshold Changes in Auditory Brainstem

この論文をさがす

説明

Auditory brainstem response (ABR) is a useful method in evaluating auditory function in human. To investigate the ABR threshold is more effective than to pursue the trends in each component of ABR. In this study, tone burst sound stimuli were employed and the ABR threshold shift caused by kanamycin administration was investigated in dogs. In a series of monitoring of ABR against short-period auditory lesions, changes in the ABR waveform after intravenous administration of kanamycin were detected. These changes returned gradually and were reversible. The changes in ABR against long-period auditory function disorder were perceived by an increase in the ABR threshold. The ABR threshold shift occurred earlier in the high frequency sounds than in the lower frequency sounds. This is why amino glycoside antibiotics damage the cochlear hair cells in the basal layer and lead to the loss of hearing selectively for high frequency tones. These findings suggest that tracing of the ABR threshold by tone bursts could provide information that has a specificity for frequency in hearing tests and is a useful method in clinical veterinary medicine or/and toxicological tests.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 45 (4), 325-331, 1996

    公益社団法人 日本実験動物学会

被引用文献 (2)*注記

もっと見る

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ