The effect of Na,K and Cl ions on the Resting Membrane Potential of Sinoatrial Node Cell of the Rabbit
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- 瀬山 一正
- Department of Physiology, School of Medicine, Hiroshima University
書誌事項
- タイトル別名
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- THE EFFECT OF Na, K AND CIIONS ON THE RESTING MEMBRANE POTENTIAL OF SINOATRIAL NODE CELL OF THE RABBIT
- effect of Na K and Cl ions on the Resti
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The resting membrane potential of S-A node cell was investigated by observing the response of the membrane potential to change in [K+] o or [Cl-] o under the presence or absence of Na ion. The slope of the change in membrane potential per decade change in [K+] o increased from 12.3 to 44 mV by removal of Na ion from the external medium, suggesting an extensive contribution of Na ion to the resting membrane potential. To determine the relative conductance between Na and K ions, Cl ion in Tyrode solution was substituted with SCN ion, which is 2.1 times more permeable than Cl ion, in order to eliminate the contribution of Cl concentration cell to the resting membrane potential. The contribution of the Cl ion to the resting membrane potential could be examined only in Na-free medium. Acetate ion has been reported to be 0.5 times less permeable than Cl ion. The replacement of Cl ion by acetate ion in various proportions caused a transient depolarization. The slope of this transient depolarization per decade change of [Cl-] o between 10 to 100mm was determined to be-6.8mV.<BR>Under the assumption that the resting membrane potential could be determined by the parallel concentration cells for Na, K and Cl, relative conductance ratio between K, Na and Cl was calculated to be 1: 0.58: 0.15.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 27 (5), 577-588, 1977
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205041942272
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- NII論文ID
- 130003476649
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DyaE1cXhtleqtL0%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 1910362
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- PubMed
- 604587
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可