Spontaneous Development of Dermatitis in DS-Nh Mice under Specific Pathogen-Free Conditions.
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- WATANABE Akira
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- TAKEUCHI Mitsuo
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- NAGATA Masafumi
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- NAKAMURA Kazuichi
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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- HIRASAWA Tsutomu
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- NAKAO Hiroyuki
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- MAKINO Susumu
- Shionogi Research Laboratories, Shionogi & Co., Ltd.
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- HARADA Minoru
- Developmental Research Laboratories, Shionogi & Co., Ltd.
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Abstract
Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions was examined to verify the hypothesis [Exp. Anim. 46: 225-229, 1997] that Stapylococcus aureus (S. aureus) infection is causally associated with the dermatitis. Observation of the mice up to 28 weeks of age indicated that obvious dermatitis does occur under S. aureus-free conditions, though the incidence was low (six of 42 females and two of 90 males). Skin lesions in the absence of this bacterium showed histological changes very similar to those that can be observed under conventional conditions. In addition, hyperproduction of serum IgE was demonstrated in the dermatitis-positive mouse. These findings suggested that the dermatitis is triggered by IgE-mediated allergic reactions.<br>
Journal
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- Experimental Animals
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Experimental Animals 52 (1), 77-80, 2003
Japanese Association for Laboratory Animal Science
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Keywords
Details 詳細情報について
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- CRID
- 1390001205041947264
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- NII Article ID
- 130000068488
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- NII Book ID
- AA11032321
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- COI
- 1:CAS:528:DC%2BD3sXhvFWjsrw%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL BIB ID
- 6410593
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- PubMed
- 12638241
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed