The Role of Membrane Electrical Activities and Extracellular Calcium in High-K-induced Contracture of Guinea Pig Ureter
書誌事項
- タイトル別名
-
- Role of Membrane Electrical Activities
この論文をさがす
抄録
Electrical and mechanical activities in high-K-induced contracture of guinea pig ureter and taenia coli were studied using the sucrose-gap method. Ureter immersed in high-K solution showed a contracture consisting of three components as well as twitch contractions evoked by a few spikes which were observed during the depolarizing phase. Reapplication of high-K solution after a short washing procedure with normal solution induced a contracture composed of only the first and the third components. No action potential was observed during the course of membrane depolarization by this procedure. High-K-induced contracture was highly sensitive to extracellular Ca: no tension development of the ureter despite the membrane depolarization was observed in Ca-free high-K solution. The addition of Ca to Ca-free high-K solution caused a contracture similar to that by high-K solution in the presence of Ca. Verapamil (10-5 M) blocked all three components, leaving only slightly depressed twitch contractions initiated by action potentials. The possibility that all of these components of high-K-induced contracture were initiated by influxed Ca from extracellular space was also strengthened.
収録刊行物
-
- The Japanese Journal of Physiology
-
The Japanese Journal of Physiology 28 (1), 1-16, 1978
一般社団法人 日本生理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205041973120
-
- NII論文ID
- 130003476663
-
- NII書誌ID
- AA00691224
-
- COI
- 1:CAS:528:DyaE1cXhvVOitLo%3D
-
- ISSN
- 18811396
- 0021521X
-
- NDL書誌ID
- 1921172
-
- PubMed
- 661011
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可