Alterations in the Rheological Flow Profile in Conduit Femoral Artery during Rhythmic Thigh Muscle Contractions in Humans

DOI Web Site PubMed 被引用文献2件 参考文献45件
  • Osada Takuya
    Department of Preventive Medicine and Public Health, Tokyo Medical University The Copenhagen Muscle Research Centre, University of Copenhagen
  • Rådegran Göran
    The Copenhagen Muscle Research Centre, University of Copenhagen Department of Cardiothoracic Surgery, The Heart and Lung Division, Lund University Hospital

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The present study examined the rheological blood velocity profile in the conduit femoral artery during rhythmic muscle contractions at different muscle forces. Eight healthy volunteers performed one-legged, dynamic knee-extensor exercise at work rates of 5, 10, 20, 30, and 40 W at 60 contractions per minute. The time and space-averaged, amplitude-weighted mean (Vmean) and maximum (Vmax) blood flow velocities in the common femoral artery were measured during the cardiosystolic phase (CSP) and cardiodiastolic phase (CDP) by the Doppler ultrasound technique. The Vmax/Vmean ratio was used as a flow profile index, in which a ratio of ∼1 indicates a “flat velocity flow profile” and a ratio significantly >1 indicates a “parabolic velocity flow profile.” At rest, the Vmax/Vmean ratio was ∼1.3 and ∼1.8 during the CSP and CDP, respectively. The Vmax/Vmean ratio was higher (p < 0.01) during the CDP than during the CSP, both at rest and at all work rates. The Vmax/Vmean ratio during the CSP was higher (p < 0.01) at 30 and 40 W compared to at rest. The Vmax/Vmean ratio during the CDP was lower (p < 0.05) at 5 and 10 W compared to at rest. There was a positive linear correlation between blood flow and incremental work rates during both the CSP and CDP, respectively. Thus under resting conditions, the findings indicate a “steeper” parabolic velocity profile during the CDP than during the CSP. The velocity profile during the CDP furthermore shifts to being less “steep” during rhythmic muscle contractions at lower intensities, but to being reelevated and normalized as at rest during higher intensities. The “steepness” of the parabolic velocity profile observed during the CSP at rest increased during muscle contraction at higher intensities. In conclusion, the blood velocity in the common femoral artery is parabolic both at rest and during exercise for both the CSP and CDP, indicating the persistence of laminar flow. The occurrence of any temporary slight disturbance or turbulence in the flow at the sight of measurement in the common femoral artery does consequently not induce a persisting “disturbed” and fully flat “plug-like” velocity profile. Instead, the “steepness” of the parabolic velocity profile is only slightly modified, whereby blood flow is not impaired. Thus the blood velocity profile, besides being influenced by the muscle contraction-relaxation induced mechanical “impedance,” seems also to be modulated by the cardiac- and blood pressure-phases, consequently influencing the exercise blood flow response.<br>

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