Role of Prostaglandin E2 and Indomethacin in the Febrile Response of Pigeons

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Intravenous (I.V.) injection of 10 μg/kg Escherichia coli lipopolysaccharide (LPS), applied at 13:00, evoked in pigeons a biphasic rise of core temperature (Tcore), so that LPS induced with a latency of 30 min first a decrease of Tcore, and 90 min after LPS, Tcore increased, obtaining maximum values from 18:00 to 20:00. Prostaglandins have been considered to be importantly involved in fevers in mammals. To investigate an involvement of prostaglandins in the cyclic variations of Tcore in birds, pigeons were injected I.V. with either 10 mg/kg indomethacin (INDO) or 100 mg/kg aspirin, or they were treated with intracerebroventricular (i.c.v.) injections of 100 μg/kg INDO at various times before or after LPS. When INDO or aspirin was I.V. injected 30 or 15 min before LPS, it diminished the initial decrease of Tcore by more than 50%, whereas the I.V. injection of these drugs 2 and 4 h after LPS did not affect the febrile rise of Tcore. i.c.v. injections of INDO given either before or after LPS neither influenced the initial drop of Tcore nor the following febrile hyperthermia. Both the I.V. injection of 1 mg/kg prostaglandin E2 (PGE2) and the i.c.v. injection of 1 μg/kg PGE2 lowered Tcore. Our observations suggest that prostaglandins are not involved in the febrile elevation of Tcore in pigeons, but appear to participate in the decrease of Tcore, which shortly follows the I.V. injection of LPS. This initial drop of Tcore following LPS may be caused by a peripheral action of prostaglandins because it was not influenced by the i.c.v. injection of indomethacin.<br>

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