Effects of Nitric Oxide Inhalation on Periodic Breathing in Awake Patients with Chronic Heart Disease.
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- Koike Akira
- The Cardiovascular Institute
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説明
Background: Periodic breathing, an abnormal pattern of respiration consisting of alternating hyperpnea and hypopnea, has been recognized in patients with heart failure. Although fluctuations in pulmonary blood flow have been considered as a possible cause of this type of breathing, its patho-physiological mechanisms are not fully understood. In this study, we sought to determine whether inhaled nitric oxide (NO), a selective pulmonary vasodilator, attenuates periodic breathing. Methods: Eight cardiac patients who exhibited clear oscillatory ventilation while awake (age: 62 ± 16 years, left ventricular ejection fraction: 48 ± 20%) were enrolled in the study. After breathing room air (RA) for 15 min, the subjects inhaled air containing 30 ppm of NO for 15 min. Respiratory gas variables including minute ventilation (V˙E) were measured on a breath-by-breath basis throughout the test. Results: There were no differences in V˙E (10.7 ± 1.5 vs. 11.0 ± 1.7 l/min) or among any of the other hemodynamic or respiratory gas variables studied in the control and NO tests, with the exception of the end-tidal CO2 partial pressure (5.0 ± 0.4 vs. 4.8 ± 0.5%; p = 0.018). The % magnitude of oscillation (i.e., the difference between the peak and nadir of oscillating V˙E, divided by the mean V˙E) was 40.0 ± 22.4% in RA and not influenced by inhaled NO (43.9 ± 20.8%, p = 0.57). Conclusion: Inhaled NO at a concentration of 30 ppm did not attenuate periodic breathing in awake patients with mild heart failure.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 52 (4), 327-332, 2002
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205042396288
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- NII論文ID
- 130004435828
- 50000691643
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD38Xps1KqsL4%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 6362632
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- PubMed
- 12519467
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可