Central Control Mechanisms of Circulation in the Medulla Oblongata by Nitric Oxide.

DOI Web Site PubMed 被引用文献2件 参考文献182件

この論文をさがす

抄録

Nitric oxide (NO) is involved in numerous physiological functions. Besides its role as an endothelium-dependent relaxing factor (EDRF), NO inhibits platelet aggregation, contributes to cytotoxicity against bacteria, is active in synaptic transmission within the brain, etc. NO synthase (NOS) is distributed in brain regions related to the regulation of cardiovascular functions. NO has been inferred not only to act directly on vascular vessels, but also to regulate circulation within the brain. In this review paper, we mainly consider the functions of NO in the cardiovascular center of the medulla oblongata. That is, we describe the anatomical distribution of NOS in the brain, effects of intravenous and intracerebroventricular administration of NOS inhibitors on the circulation, effects of microinjection of NO donors and NOS inhibitors into the nucleus tractus solitarius (NTS) and ventrolateral medulla (VLM), the results of electrophysiological studies on these areas, and finally, the data obtained by new molecular biological techniques.<br>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (182)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ