Asphyxia and Diuretic-Induced Changes in the Ca〔2+〕 Concentration of Endolymph
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- Takamaki Atsuko
- Department of Physiology II, Osaka Medical College
書誌事項
- タイトル別名
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- Asphyxia and Diuretic-Induced Changes in the Ca2+ Concentration of Endolymph.
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説明
Using Ca2+-selective microelectrodes based on the neutral carrier, ETH-1001 with polyvinyl chloride (PVC), we have measured changes in the free Ca2+ concentration of guinea pig cochlear endolymph ([Ca]e) after transient asphyxia or intravenous administration of diuretics. Under the control conditions, the endocochlear potential (EP) was +80 mV, and the [Ca]e was in the range 1.4×10−7–2.4×10−6 M (n = 16). Transient asphyxia (1–1.5 min) produced an increase in the [Ca]e with a fall in the EP, whereas the cessation of the asphyxia led to a quick recovery of both [Ca]e and EP to their control levels. Intravenous administration of furosemide (60 mg/kg) or bumetanide (30 mg/kg) also caused an increase in the [Ca]e with a fall in the EP, followed by a gradual recovery of both [Ca]e and EP. From these results, we obtained a significant correlation between EP and p[Ca]e (= –log[Ca]e), and conclude that (1) the [Ca]e is extremely low, around 10−6 M or less, under normal conditions and (2) the [Ca]e is directly correlated with EP under physiological conditions.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 53 (1), 35-44, 2003
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205042590592
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- NII論文ID
- 10010531452
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD3sXjsVWiurc%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 6498408
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- PubMed
- 12689356
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
