EFFECT OF THE LOCAL ANESTHETIC QUATACAINE ON THE MEMBRANE POTENTIAL AND SODIUM CONDUCTANCE OF FROG MUSCLE FIBERS

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  • 赤池 紀扶
    Biological Research and Product Control Laboratories, Tanabe Seiyaku Company, Ltd.
  • 野田 浩逸
    Biological Research and Product Control Laboratories, Tanabe Seiyaku Company, Ltd.

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1) The effects of the local anesthetic, quatacaine, on the sartorius muscle fibers of frog have been investigated using an intracellular recording technique, in order to compare them with those of procaine and tetrodotoxine (TTX).<BR>2) Quatacaine increased the electrical threshold of the muscle fiber membrane and reduced or abolished the action potential without affecting the resting potential. These effects of quatacaine were dose-dependent and they were affected by the concentration of sodium in the external solution.<BR>3) Quatacaine and procaine (0.06%) inhibited slightly the delayed recovery and increased the “input” resistance while TTX (10-7g/ml) had no effect.<BR>4) When the observed membrane constants were used in calculating the maximum sodium conductance (gNa), gNa decreased from 19.5 to 6.1 mmho/cm2 after the addition of quatacaine (0.03%).<BR>5) It was concluded that quatacaine affects the muscle membrane by diminishing greatly the selective sodium conductance in the active membrane and by reducing slightly the potassium conductance simultaneously in both the resting and active membranes.

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