FORCE-LOAD-VELOCITY RELATION AND THE INTERNAL LOAD OF TETANIZED FROG CARDIAC MUSCLE

DOI Web Site PubMed 被引用文献1件
  • 真島 英信
    Department of Physiology, School of Medicine, Juntendo University

書誌事項

タイトル別名
  • Force Load Velocity Relation and the In

この論文をさがす

抄録

A frog ventricular muscle strip could be fully tetanized by alternating current stimulation at 10Hz and 20V/cm in a solution containing 9mM Ca2+.During isometric tetanus, the controlled release was made and the shortening velocities against various loads were measured.The isometric force was varied by reducing the stimulus intensity in K+-rich solution, or by reducing the external Ca2+ concentration. The force-load-velocity relation was described by a simple hyperbolic equation:(P+A)(ν+b) =b(F+A), A=(F/Fm) a for shortening, and (2F-P+A')(-ν+b') =b'(F+A'), A'=(F/Fm) a' for lengthening, where F is the isometric force, Fm is the maximum isometric force at the optimal muscle length, Lm, P is the load, ν is the velocity, a, b, a' and b'are constants. The values of constants were a/Fm=0.51, b=0.75 Lm/sec for shortening and a'/Fm=0.39, b'=0.75 Lm/sec for lengthening at 20°C. At muscle lengths shorter than 0.92 Lm, the internal load defined as the difference between the external load and calculated load at a given velocity increased in proportion to both the velocity and the decrease in muscle length.

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ