A Congenic Strain(F344.OLETF-Imfm) Displays the Existence of Intramuscular Fat Accumulation QTL on Rat Chromosome 1.

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  • TANOMURA Hideki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
  • TANIGUCHI Yukio
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
  • MURAMATSU Youji
    Department of Food Science, Shizuoka Eiwa College
  • KOSE Hiroyuki
    Institute for Animal Experimentation, University of Tokushima School of Medicine
  • MIYAKE Takeshi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
  • MATSUMOTO Kozo
    Institute for Animal Experimentation, University of Tokushima School of Medicine
  • YAMADA Takahisa
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
  • SASAKI Yoshiyuki
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University

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タイトル別名
  • Congenic Strain F344 OLETF Imfm Displays the Existence of Intramuscular Fat Accumulation QTL on Rat Chromosome 1

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説明

A genomic region between D1Wox8 and D1Rat90 on rat chromosome 1 was previously shown to be linked to intramuscular fat accumulation by quantitative trait locus (QTL) analysis using a F2 population derived from the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, which exhibits an increase in the levels of intramuscular fat content in Musculus longissimus, and the F344 rat. There exist two regions showing major and minor lod peaks for linkage to intramuscular fat accumulation, in the chromosomal region. We constructed a congenic strain introgressing the OLETF allele on the minor but not the major lod peak region in the F344 rat strain. The congenic strain had higher levels of intramuscular fat content in Musculus longissimus than the inbred partner F344 rat, thereby proving the existence of a QTL, designated Imfm (for Intramuscular fat-minor), responsible for the intramuscular fat accumulation in the congenic region of the minor lod peak region of about 10 cM. The F344.OLETF-Imfm congenic strain might provide a refined tool for the analysis of the gene causing intramuscular fat accumulation.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 52 (4), 303-308, 2003

    公益社団法人 日本実験動物学会

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