ELECTROPHYSIOLOGICAL PROPERTIES OF THE SMOOTH MUSCLE CELLS OF THE BILIARY SYSTEM OF THE GUINEA-PIG

DOI Web Site PubMed
  • CREED K. E.
    Department of Physiology, Faculty of Dentistry, Kyushu University
  • 栗山 煕
    Department of Physiology, Faculty of Dentistry, Kyushu University

この論文をさがす

抄録

1. The electrical activity and biophysical properties of the gall bladder and bile duct of the guinea-pig were investigated with microelectrodes. In addition, the relationship between the activity of the bile duct and that of the duodenum was observed.<BR>2. In the gall bladder the mean resting potential was -36.9mV and there was usually no activity in Krebs solution. Ba++, Ach or TEA depolarized the membrane (to 27.4mV in 2.5mm TEA) and initiated a spike discharge in bursts. The spikes had overshoots and plateaus on the falling phase. The time course of the foot of the spike was about 45msec.<BR>3. Simultaneous records from 2 cells showed good synchronization of spikes which normally occurred first at the bile duct end. The conduction velocity measured from the interval between spontaneous spikes recorded from 2cells or from the latency after electrical stimulation was 4.2-8.5mm/sec.<BR>4. The mean resting potential of the ampulla region of the bile duct was 51.3mV and of the rest of the bile duct was 38.6mV. Spontaneous bursts of spikes some with overshoots, occurred in the Krebs solution. The time course of the foot of the spike was about 11msec.<BR>5. Synchronization of bursts but not individual spikes occurred. The conduction velocity of evoked or spontaneous spikes was usually 23-27mm/sec, but a wide scatter of values was obtained.<BR>6. No electrical activity could be recorded from the hepatic ducts or from the cystic and bile ducts close to the hepatic ducts.<BR>7. When the electrical activities of the ampulla and of the duodenum 1mm away were recorded simultaneously, no synchronization was observed between the two regions.<BR>8. For both the gall bladder and bile duct the length constant (λ) was 0.7-0.8mm. The time constant of the membrane (Tm) was less than 100msec but could not be measured accurately.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ