Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice.

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  • NAKAMURA Moritaka
    Department of Microbiology/Immunology, Hamamatsu University School of Medicine
  • NISHIMURA Masahiko
    Institute for Experimental Animals, Hamamatsu University School of Medicine
  • KOIDE Yukio
    Department of Microbiology/Immunology, Hamamatsu University School of Medicine
  • YOSHIDA Takato O.
    Department of Microbiology/Immunology, Hamamatsu University School of Medicine

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  • Analysis of Pathogenesis of Autoimmune

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In an effort to study the pathophysiological events in the development of insulitis in NOD mice, we have developed ILI- and NOD-nu/nu mice. ILI mice are a nondiabetic inbred strain but are derived from the same Jcl:ICR mouse as NOD mice and share the same H-2 allotype with NOD mice. Splenocytes and CD4+ cells from diabetic NOD mice appeared to transfer insulitis to ILI-nu/nu mice, suggesting that ILI mice already express autoantigen(s) responsible for insulitis. But reciprocal thymic grafts from NOD mice into ILI-nu/nu mice and those from ILI mice into NOD-nu/nu mice failed to allow the development of insulitis, implying that ILI mice possess neither precursor T cells nor the thymic environment responsible for the development of insulitis. In addition, splenocytes from ILI mice appeared to contain regulatory cells which suppress the development of diabetes but not that of insulitis in NOD mice. The use of these nude mice should provide more information on the products of insulitis-susceptibility genes of NOD mice.<br>

Journal

  • Experimental Animals

    Experimental Animals 45 (3), 233-238, 1996

    Japanese Association for Laboratory Animal Science

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