Selective Inhibition of Potassium Contracture in Guinea Pig Taenia Coli by Ruthenium Red
書誌事項
- タイトル別名
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- Selective Inhibition of Potassium Contr
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Effects of ruthenium red on isotonic KCl induced contracture (K-contracture), cellular 45Ca uptake and 45Ca binding to surface membranes were examined in the smooth muscle cells of guinea pig taenia coli. These results were compared with those using lanthanum (La3+).<BR>The tonic component of the K-contracture was selectively inhibited by 1 mM ruthenium red. In contrast, 1 mivt La3+ inhibited the phasic component of the K-contracture to a large extent. Use of 1 mM ruthenium red selectively inhibited the tonic component of K-contracture and caused a marked decrease in cellular 45Ca uptake in that component of K-contracture. In contrast, 1 mM La3+ largely inhibited the phasic component and caused a significant decrease in cellular 45Ca in that component. According to Scatchard plot analysis, there are two kinds of Ca2+ binding sites of high and low affinity, respectively, on the surface membrane of the taenia coli. One mM ruthenium red suppressed those of low affinity more strongly than those of high affinity. In contrast, 1 mM La3+ suppressed high affinity sites more markedly than low affinity sites.<BR>Based on these results, it seems possible to conclude that ruthenium red mainly blocks the initial binding sites linked with Ca2+ influx which is related to the production of the tonic component while La3+ blocks those sites related to the phasic component of the K-contracture of guinea pig taenia coli.
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 28 (4), 447-460, 1978
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205043394944
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- NII論文ID
- 130003476680
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- NII書誌ID
- AA00691224
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- COI
- 1:CAS:528:DyaE1MXhvF2qtQ%3D%3D
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 1921196
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- PubMed
- 722992
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可