THE EFFECT OF TETRODOTOXIN ON CALCIUM-DEPENDENT LINK IN STIMULUS-SECRETION COUPLING IN NEUROHYPOPHYSIS

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  • 石田 絢子
    Department of Physiology, School of Medicine, Juntendo University

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1. Studies have been made on the effect of tetrodotoxin for vasopressen release from the isolated pituitary gland of the rat and Ca movement in relation to the secretion.<BR>2. The presence of tetrodotoxin in incubation media suppressed markedly (80%) the vasopressin release caused by the exposure of the gland to excess K solution. Such a suppression can also persist in Na-deficient media. 45Ca movements of both efflux and influx under the exposing excess K are also suppressed by about 35%. However, apparent suppression by tetrodotoxin on vasopressin release and Ca movement were not seen at the resting state.<BR>3. The potentiation of secretion caused by low temperature or the presence of SH reagent was not suppressed by tetrodotoxin.<BR>4. The primary effect of tetrodotoxin is a suppression of the Ca movement in stimulus-secretion coupling, then secondarily the vasopressin output is suppressed.<BR>5. The observations by electron microscope are considerably consistent with the experiment of vasopressin release.

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