Hypoxia-Induced Adaptational Shift in MHC-β Isoform Expression in Rat Ventricles
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- Hashimoto Takeshi
- Graduate School of Human and Environmental Studies, Kyoto University
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- Sugiyama Atsushi
- Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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- Taguchi Sadayoshi
- Graduate School of Human and Environmental Studies, Kyoto University
書誌事項
- タイトル別名
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- Hypoxia-Induced Adaptational Shift in MHC-.BETA. Isoform Expression in Rat Ventricles
- Hypoxia Induced Adaptational Shift in MHC ベータ Isoform Expression in Rat Ventricles
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抄録
We investigated whether the shift of cardiac myosin heavy chain (MHC) isoform observed during exposure to hypoxia is secondary to hypertrophy, or whether it is directly related to the hypoxic stress. Twelve male Wistar-Kyoto rats, 14 weeks old, were randomly assigned to two groups: sea-level control group (CO) and hypoxia group (HX). The CO group was housed 4 weeks at 1,011 hPa, and the HX group was housed for 4 weeks at 701 hPa. The expression of MHC-β was significantly increased (600%) in the HX group as compared to the CO group in the right ventricle (p < 0.01). An increased ventricular mass induced by hypoxic exposure was associated with an increased expression of MHC-β in the right ventricle (p < 0.05). In the left ventricle, the MHC-b expression was significantly increased (295%) in the HX group as compared to the CO group without ventricular hypertrophy (p < 0.01). No differences were observed in the adenylyl cyclase activity or in the phosphodiesterase activities in both ventricles between the CO and HX groups (p > 0.05). Oxidative enzymatic activities (citrate synthase and three-hydroxyacyl-CoA dehydrogenase) were unchanged in both ventricles following 4 weeks of hypoxia (p > 0.05). These findings suggest that, besides cardiac hypertrophy, the hypoxia-induced adaptational change to the MHC-b isoform may be mediated through a specific mechanism related to the stress of hypoxia.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 55 (2), 109-115, 2005
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205043495552
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- NII論文ID
- 10016627349
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- NII書誌ID
- AA00691224
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- ISSN
- 18811396
- 0021521X
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- NDL書誌ID
- 7362140
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- PubMed
- 15862134
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可