β-Adrenoceptor Agonist Clenbuterol Down-Regulates Matrix Metalloproteinase (MMP-9) and Results in an Impairment of Collagen Turnover in Mice Left Ventricle
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- Patiyal Som N.
- Department of Biosciences, Himachal Pradesh University
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- Katoch Surender S.
- Department of Biosciences, Himachal Pradesh University
書誌事項
- タイトル別名
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- .BETA.-Adrenoceptor Agonist Clenbuterol Down-Regulates Matrix Metalloproteinase (MMP-9) and Results in an Impairment of Collagen Turnover in Mice Left Ventricle
- 公開日
- 2005
- DOI
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- 10.2170/jjphysiol.r2118
- 公開者
- 一般社団法人 日本生理学会
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説明
An oral administration of a single dose of β-adrenoceptor agonist clenbuterol (15 mg/kg body weight) to mice resulted in an increased collagen distribution in the subendocardium and myocardium of the left ventricle. Abundant collagen accumulation is characteristic in myonecrotic regions and around blood vessels. Hydroxyproline assay and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) of pepsin insoluble collagen confirmed this stimulated collagen proliferation. An MMP-activity assay of tissue extract by gelatin in gel zymography demonstrated a significant inhibition of MMP-9 activity in the β-agonist–treated group. The results suggest that clenbuterol treatment is capable of inducing structural and functional remodeling of the extracellular matrix by down-regulating MMP-9 activity and thereby causing an impairment of collagen turnover. This may lead to changes in the different hemodynamic properties of the tissue, including ventricular compliance.<br>
収録刊行物
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 55 (3), 165-172, 2005
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205043665664
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- NII論文ID
- 130004435927
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- ISSN
- 18811396
- 0021521X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
