Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in l996

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  • IKEGAMI Tetsuro
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • MIRANDA Mary Elizabeth G
    Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health
  • CALAOR Alan B
    Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health
  • MANALO Daria L
    Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health
  • MIRANDA Noel J
    INA Research Philippines, Inc.
  • NIIKURA Masahiro
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
  • SAIJO Masayuki
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
  • UNE Yumi
    Laboratory of Veterinary Pathology, Azabu University
  • NOMURA Yasuo
    Laboratory of Veterinary Pathology, Azabu University
  • KURANE Ichiro
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases
  • KSIAZEK Thomas G
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention
  • YOSHIKAWA Yasuhiro
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • MORIKAWA Shigeru
    Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases

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タイトル別名
  • Histopathology of Natural Ebola Virus Subtype Reston Infection in Cynomolgus Macaques during the Philippine Outbreak in 1996.

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抄録

We investigated the livers, spleens, kidneys and lungs collected from 24 cynomolgus macaques (Macaca fascicularis) naturally infected with Ebola virus subtype Reston (EBO-R) during the Philippine outbreak in 1996, in order to reveal the histopathologic findings. These macaques showed necrotic hepatocytes with inclusions, slight to massive fibrin deposition in splenic cords, depletion of lymphoid cells in the white pulp of the spleen, and fibrin thrombi in some organs. Immunohistochemical analysis using anti-leukocyte antigen L1 antibody revealed an increase in blood-derived macrophages/monocytes in the livers, kidneys and lungs of EBO-R infected macaques. EBO-R NP antigens were detected in the macrophages/monocytes, endothelial cells and fibroblasts in the liver, spleen, kidney and lung. These results indicate that EBO-R infection is characterized by systemic coagulopathy and an increase in blood-derived macrophages/monocytes in accordance with the EBO-R propagation in macrophages/monocytes.

収録刊行物

  • Experimental Animals

    Experimental Animals 51 (5), 447-455, 2002

    公益社団法人 日本実験動物学会

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