Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

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  • CHEN Yang
    Tsukuba Primate Center, National Institute of Infectious Diseases Seiwa Pharmaceutical, Ltd.
  • SHIMIZU Masaru
    Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd.
  • SATO Katsuhiko
    Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd.
  • KOTO Masao
    Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd.
  • TSUNEMI Kunihiko
    Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd.
  • YOSHIDA Takashi
    Tsukuba Primate Center, National Institute of Infectious Diseases
  • YOSHIKAWA Yasuhiro
    Tsukuba Primate Center, National Institute of Infectious Diseases Department of Biomedical Science, Faculty of Agriculture, University of Tokyo

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Age-related changes in bone mineral content and bone biomarkers were assessed over the complete lifespan of female cynomolgus monkeys. The bone mass of the lumbar spine increased linearly from birth to about 2.5 years of age, and this increase gradually slowed thereafter until a peak bone mass was achieved at 9 years of age. The bone mass stabilized after 9 years of age, showing no sign of further reduction with age. In contrast with the significant increase in bone mass before 2.5 years of age, significant decreases occurred in the serum concentrations of the following bone formation markers: intact osteocalcin, bone-specific alkaline phosphatase and amino-terminal propeptide of type I procollagen, but the serum concentration of carboxy-terminal propeptide of type I procollagen did not change significantly throughout the entire lifespan. Concerning the bone resorption markers, the levels of tartrate-resistant acid phosphatase fluctuated throughout the entire lifespan. The skeleton of an aging female monkey undergoes changes similar to those observed in senescent humans, but did not undergo the menopausal changes seen in women. The use of female cynomolgus monkeys to model human skeletal interventions should therefore be undertaken with consideration of the similarities and differences between cynomolgus monkeys and humans.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 49 (3), 163-170, 2000

    公益社団法人 日本実験動物学会

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