Effect of Erythromycin on Macrophage Functions

DOI Web Site PubMed 7 Citations 20 References

Bibliographic Information

Other Title
  • エリスロマイシンのマクロファージ機能に対する影響
  • エリスロマイシン ノ マクロファージ キノウ ニ タイスル エイキョウ

Search this article

Abstract

Recently, it has been suggested that macrolide antibiotics act as immunomodulators. In this study, we evaluated the effect of EM on macrophage function. We used the mouse macrophage cell line, J774.1. The following direct effects of EM on macrophage function were evaluated: chemotaxis to EM, chemokinetic effect by EM, and the effect of EM on macrophage growth. In order to examine the indirect effects of EM on macrophage functions, we preincubated macrophages with several concentrations of EM and then removed the EM. Thereafter, the phagocytosis of beads, cytocidal activity against Candida albicans, and chemotaxis to lipopolysaccharide were evaluated. EM (at the concentration between 0.04 and 0.2μg/ml) directly stimulated macrophage chemotaxis and chemokinesis. In addition, EM dose-dependently stimulated the growth of macrophages. EM pretreatment (for 4 hours at the contrations between 0.04 and 0.2μg/ml) stimulated macrophage phagocytosis, cytocidal activity against Candida albicans, and chemotaxis to lipopolysaccharide. These results suggest that EM has direct and indirect effects on macrophage functions.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69 (5), 590-596, 1995

    The Japanese Association for Infectious Diseases

Citations (7)*help

See more

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top