Clinical Usefulness of Microparticle Enzyme Immunoassay for HBeAg and HBeAb in Chronic Hepatitis B Patients

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  • YAMASHITA Naoko
    The Laboratory for Clinical Investigation, Osaka University Hospital
  • DEGUCHI Matsuo
    The Laboratory for Clinical Investigation, Osaka University Hospital
  • HOSOTSUBO Hideo
    The Laboratory for Clinical Investigation, Osaka University Hospital
  • ASARI Seishi
    The Laboratory for Clinical Investigation, Osaka University Hospital

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Other Title
  • B型慢性肝炎患者におけるMicroparticle EIAによるHBe抗原・抗体の有用性
  • Bガタ マンセイ カンエン カンジャ ニ オケル Microparticle

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Abstract

A study was made of 73 samples from 6 chronic hepatitis B patients, 2 out of the 6 cases were non-treated and the 4 cases were interferon treated HBeAg, HBeAb, s-ALT and HBV-DNA.<BR>Detection of HBeAg and HBeAb were assayed by AxSYM system (Dainabot), which were based on microparticle enzyme immunoassay.<BR>1) Fifty-three out of 73 samples showed positive for HBeAg; 45 samples showed only HBeAg positive (Group A) and 8 samples showed HBeAg and HBeAb positive (Group B). The positive ratios of HBV-DNA in each group 91.1%(41/45) and 50.0%(4/8), respectively and 4 out of the rest 20 samples that showed only HBeAb positive also showed HBV-DNA positive. The above 12 discrepant samples between HBeAg and HBV-DNA were collected from 4 chronic hepatitis B patients who became normal s-ALT levels after liver injury. The HBeAg S/N ratio (sample/negative control) of these samples were near the cutoff value (S/N =2.1).<BR>2) Comparing the movement between HBeAg and s-ALT levels in 6 chronic hepatitis B patients, the changes of HBeAg S/N ratio were related with the changes of s-ALT. The changes of HBeAg S/N ratio were observed before the movement of s-ALT.<BR>In conclusion, the detection of HBeAg/HBeAb by AxSYM system was useful to monitor the clinical course of chronic hepatitis B patients.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69 (12), 1323-1328, 1995

    The Japanese Association for Infectious Diseases

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