Effects of Air Transportation Cause Physiological and Biochemical Changes Indicative of Stress Leading to Regulation of Chaperone Expression Levels and Corticosterone Concentration

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  • SHIM SunBo
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • LEE SeHyun
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • KIM ChuelKyu
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • KIM ByoungGuk
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • JEE SeungWan
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • LEE SuHae
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • SIN JiSoon
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • BAE ChangJoon
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • WOO Jong-Min
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • CHO JungSik
    Multidisciplinary Technology Institute, Hoseo University
  • LEE EonPil
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • CHOI HaeWook
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • KIM HongSung
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • LEE JaeHo
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • JUNG YoungJin
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • CHO ByungWooK
    Department of Animal Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
  • CHAE KabRyong
    Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
  • HWANG DaeYoun
    Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center

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Abstract

Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress.<br>

Journal

  • Experimental Animals

    Experimental Animals 58 (1), 11-17, 2009

    Japanese Association for Laboratory Animal Science

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