Effects of Air Transportation Cause Physiological and Biochemical Changes Indicative of Stress Leading to Regulation of Chaperone Expression Levels and Corticosterone Concentration
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- SHIM SunBo
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- LEE SeHyun
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- KIM ChuelKyu
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- KIM ByoungGuk
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- JEE SeungWan
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- LEE SuHae
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- SIN JiSoon
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- BAE ChangJoon
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- WOO Jong-Min
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- CHO JungSik
- Multidisciplinary Technology Institute, Hoseo University
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- LEE EonPil
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- CHOI HaeWook
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- KIM HongSung
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- LEE JaeHo
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- JUNG YoungJin
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- CHO ByungWooK
- Department of Animal Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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- CHAE KabRyong
- Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA
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- HWANG DaeYoun
- Department of Biomaterial Science, College of Natural Resources & Life Science, Pusan National University/PNU-Laboratory Animal Resources Center
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説明
Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 58 (1), 11-17, 2009
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205045218432
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- NII論文ID
- 10024837859
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 9760739
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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