Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats

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  • KOSE Hiroyuki
    Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School Present address: Department of Life Science, Division of Natural Sciences, International Christian University
  • SADO Yoshikazu
    Division of Immunology, Shigei Medical Research Institute
  • YAMADA Takahisa
    Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
  • MATSUMOTO Kozo
    Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School

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Description

Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F1 (WKY × DA) × WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.<br>

Journal

  • Experimental Animals

    Experimental Animals 58 (2), 193-198, 2009

    Japanese Association for Laboratory Animal Science

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