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- KANKI Hiroaki
- Laboratory for Behavioral Genetics, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN)
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- SUZUKI Hitomi
- Laboratory for Behavioral Genetics, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN)
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- ITOHARA Shigeyoshi
- Laboratory for Behavioral Genetics, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN)
書誌事項
- タイトル別名
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- High-efficiency CAG-FLPe Deleter Mice in C57BL/6J Background
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The increasing popularity of conditional knockout (KO) technology has resulted in the demand for efficient FLP deleter mice. In addition, FLP deleters are needed in genetic backgrounds that are suited to behavioral studies. We generated CAG-FLPe transgenic (Tg) mice with the C57BL/6J genetic background, which is one of the most commonly-used strains in behavioral studies. We assessed the recombination efficiency of the CAG-FLPe-Tg lines by crossing them with a mouse line carrying a FRT-PGK-neo-FRT cassette. Four of five independent CAG-FLPe lines induced recombination in most (91%-100%) of their progenies, although a small fraction (0%-30%, depending on the line) showed mosaic recombination patterns. These animals are highly potent as deleters of FRT cassettes and are useful for behavioral studies involving conditional KO mice.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 55 (2), 137-141, 2006
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205045343616
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- NII論文ID
- 10018114740
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 7881144
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可